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Cobalt (III) Protoporphyrin IX chloride

Heme oxygenase activator
 
ALX-430-076-M025 25 mg 99.00 USD
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The ability of cobalt ions to induce heme oxygenase (HO) activity in liver cells was first reported almost 30 years ago. Cobalt protoporphyrin IX (CoPP) was later shown to be a substrate for HO, now identified as the inducible isoform HO-1 (heast shock protein 32; hsp32). CoPP has been shown to down-regulate various cytochrome P450 isoforms and various mechanisms of action have been attributed to CoPP and other metalloporphyrins.

Product Specification

Formula:C34H32CoN4O4 . Cl
 
MW:654.5
 
CAS:102601-60-5
 
Purity:≥95% (TLC)
 
Identity:Identity determined by UV/VIS, NMR and MS.
 
Appearance:Dark purple solid.
 
Solubility:Soluble in basic aqueous solutions at pH between 8.5-9.0. Once in solution pH can be adjusted to physiological pH.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light and moisture.
 
430-076
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430-076

Product Literature References

Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR: N.G. Abraham et al.; Cell Mol Biol (Noisy-le-grand) 48, 895 (2002), Abstract;
Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury: F. Amersi et al.; J. Clin. Invest. 104, 1631 (1999), Abstract;
Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response: E.E. Cable et al.; Mol. Cell. Biochem. 169, 13 (1997), Abstract;
Depletion of cytochrome P-450 by thyroid hormone and cobalt-protoporphyrin IX in rat liver: evidence that susceptibility varies among forms of the heme protein: D.W. Rosenberg et al.; Pharmacology 51, 254 (1995), Abstract;
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver: M.D. Maines et al.; PNAS 73, 1499 (1976), Abstract;
Activity of various metalloporphyrin protein complexes with microsomal heme oxygenase: B.A. Schacter & M.R. Waterman; Life Sci. 14, 47 (1974), Abstract;
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity: M.D. Maines & A. Kappas ; PNAS 71, 4293 (1974), Abstract;

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