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MnTBAP chloride

SOD mimetic. Peroxynitrite scavenger.
 
ALX-430-069-M010 10 mg 37.00 USD
 
ALX-430-069-M050 50 mg 99.00 USD
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Replaces Prod. #: BML-FR107

Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Inhibits neuronal apoptosis.

Product Specification

Formula:C48H28MnN4O8Cl
 
MW:879.2
 
Purity:≥95% (TLC)
 
Appearance:Black crystalline powder.
 
Solubility:Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 2 years after receipt when stored at -20°C.
 
430-069
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Product Literature References

Ao Overproduction of nitric oxide by endothelial cells and macrophages contributes to mitochondrial oxidative stress in adrenocortical cells and adrenal insufficiency during endotoxemia: C.N. Wang, et al.; Free Radic. Biol. Med. 83, 31 (2015), Application(s): Injection, Abstract;
Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis: H. Dussmann, et al.; J. Biol. Chem. 278, 12645 (2003), Abstract; Full Text
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen.: S. Kotamraju, et al.; J. Biol. Chem. 275, 33585 (2000), Abstract; Full Text
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem. 275, 13613 (2000), Abstract; Full Text
Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation: P. Ghafourifar, et al.; J. Biol. Chem. 274, 31185 (1999), Abstract; Full Text
Reactive oxygen species regulate activation-induced T cell apoptosis:: D.A. Hildeman, et al.; Immunity 10, 735 (1999), Abstract;
Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabó, et al.; FEBS Lett. 381, 82 (1996), Abstract;
A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther. 275, 1227 (1995), Abstract;
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994), Abstract; Full Text

General Literature References

Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic: M. Patel; J. Neurochem. 71, 1068 (1998), Abstract;
The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock: B. Zingarelli, et al.; Br. J. Pharmacol. 120, 259 (1997), Abstract;

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