Replaces Prod. #: BML-CN235
Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.
Product Details
| Formula: | C34H32N4O4Zn |
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| MW: | 626.0 |
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| CAS: | 15442-64-5 |
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| Purity: | ≥95% (TLC) |
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| Identity: | Identity determined by UV and NMR. |
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| Appearance: | Dark solid. |
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| Solubility: | Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 3 years after receipt when stored at -20°C. Make solutions fresh daily. Product may be unstable in solution if exposed to light. |
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| Handling: | Protect from light and moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Heme oxygenase-1 in the spinal cord plays crucial roles in the analgesic effects of pregabalin and gabapentin in a spared nerve-injury mouse model: K. Godai, et al.; Neurosci. Lett.
767, 136310 (2022),
Abstract;
5-Aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis-induced acute kidney injury: A. Uchida, et al.; Nephrology (Carlton)
24, 28 (2019),
Application(s): Treatment of mice,
Abstract;
The apolipoprotein A-I mimetic peptide, D-4F, alleviates ox-LDL-induced oxidative stress and promotes endothelial repair through the eNOS/HO-1 pathway: D. Liu, et al.; J. Mol. Cell. Cardiol.
105, 77 (2017),
Abstract;
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways: C. Zhang, et al.; Redox Biol.
11, 1 (2016),
Abstract;
Full Text
Cross-talk between two antioxidants, thioredoxin reductase and heme oxygenase-1, and therapeutic implications for multiple myeloma: P.V. Raninga, et al.; Redox Biol.
8, 175 (2016),
Application(s): Control of ZnPP IX,
Abstract;
Expression of the thioredoxin system in an in vivo-like cancer cell environment upon auranofin treatment: M. Bhatia, et al.; Eur. J. Cell Biol.
95, 378 (2016),
Application(s): Evaluation of auranofin induced cytotoxicity,
Abstract;
Anti-inflammatory effect of pachymic acid promotes odontoblastic differentiation via HO-1 in dental pulp cells.: Y.H. lee, et al.; Oral Dis.
19, 193 (2013),
Application(s): Treatment of human dental pulp cell culture,
Abstract;
Heme oxygenase-1 promotes angiogenesis in
urothelial carcinoma of the urinary bladder: M. Miyake, et al.; Oncol. Rep.
25, 653 (2011),
Application(s): Treatment of human high-grade invasive bladder tumor cell line in culture,
Abstract;
Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX: S. Rattan, et al.; Am. J. Physiol.
276, G138 (1999),
Abstract;
Full Text
Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity: L. Serfass and J.N. Burstyn; Arch. Biochem. Biophys.
359, 8 (1998),
Abstract;
Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock: S.F. Yet, et al.; J. Biol. Chem.
272, 4295 (1997),
Abstract;
Full Text
Pitfalls using metalloporphyrins in carbon monoxide research: L. Grundemar and L. Ny; TIPS
18, 193 (1997), (Review),
Abstract;
Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter: S. Chakder, et al.; J. Pharmacol. Exp. Ther.
277, 1376 (1996),
Abstract;
Inhibition of nitric oxide synthase isoforms by porphyrins: D.J. Wolff, et al.; Arch. Biochem. Biophys.
333, 27 (1996),
Abstract;
Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase: L. Ny, et al.; Br. J. Pharmacol.
115, 186 (1995),
Abstract;
Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats: C. Kadoya, et al.; Stroke
26, 1035 (1995),
Abstract;
Full Text
Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function: G.S. Marks, et al.; Can. J. Physiol.Pharmacol.
71, 753 (1993),
Abstract;
Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus: M. Zhuo, et al; Science
260, 1946 (1993),
Abstract;
Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase: B. Brune & V. Ullrich; Mol. Pharmacol.
32, 497 (1987),
Abstract;
General Literature References
Gases as biological messengers: nitric oxide and carbon monoxide in the brain: T.M. Dawson & S.H. Snyder; J. Neurosci.
14, 5147 (1994),
Abstract;
Carbon monoxide: a putative neural messenger: A. Verma, et al.; Science
259, 381 (1993),
Abstract;
