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DEA NONOate

Nitric oxide donor
 
ALX-430-034-M010 10 mg 34.00 USD
 
ALX-430-034-M050 50 mg 60.00 USD
 
ALX-430-034-5005 5x5 mg 88.00 USD
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Nitric oxide (NO) donor.

Product Specification

Alternative Name:DEA/NO, 2-(N,N-Diethylamino)-diazenolate-2-oxide . diethylammonium salt
 
Formula:C4H10N3O2 . C4H12N
 
MW:132.1 . 74.1
 
CAS:372965-00-9
 
Purity:≥98% (NMR)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in 100% ethanol (25mg/ml), DMSO (2mg/ml), dimethyl formamide (2mg/ml) or PBS, pH 7.2 (10mg/ml).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:Store, as supplied, at-80°C for up to 1 year.  Aqueous solutions should be prepared fresh daily.
 
Handling:Protect from light and oxygen. Packaged under inert gas. Hygroscopic.
 
Technical Info/Product Notes:Dissociates to the free amine and nitric oxide in a pH-dependent manner following first order kinetics. To initiate the release of nitric oxide, add stock alkaline solution of DEA NONOate to excess buffer of pH 7.0 - 7.4. The half life in 0.1 M phosphate buffer, pH 7.4, is t½ = 16 min. at 22 -25 °C or t½= 2 min. at 37 °C. Liberates 1.5 mol of NO per mol of parent compound. Decomposition is nearly instantaneous at pH 5.0.
 
430-034
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430-034

Product Literature References

Involvement of Heme Oxygenase-1 in particulate matter-induced impairment of NO-dependent relaxation in rat intralobar pulmonary arteries: M. Barrier, et al.; Toxicol. In Vitro 32, 205 (2016), Application(s): Cell culture, Abstract;
Endogenous oestrogens do not regulate endothelial nitric oxide production in early postnatal rats: S.I. Sofronova, et al.; Eur. J. Pharmacol. 765, 598 (2015), Abstract;
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl: M.M. Cortese-Krott, et al.; PNAS 112, e4651 (2015), Application(s): Cell culture, Abstract; Full Text
Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation: M. Shelly, et al.; Science 327, 547 (2010), Abstract;
Effect of endogenous and exogenous nitric oxide on calcium sparks as targets for vasodilation in rat cerebral artery: M. Mandala, et al.; Nitric Oxide 16, 104 (2007), Abstract;
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients: J.S. Isenberg, et al.; Free Radic. Biol. Med. 40, 1028 (2006), Abstract;
Nitric oxide mediates interactions between GABAA receptors and adenosine A1 receptors in the rat hippocampus: I.R. Fragata, et al.; Eur. J. Pharmacol. 543, 32 (2006), Abstract;
A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations: M.S. Crane, et al.; Br. J. Pharmacol. 144, 849 (2005), Abstract;
Flavin-containing monooxygenase activity can be inhibited by nitric oxide-mediated S-nitrosylation: S.D. Ryu, et al.; Life Sci. 75, 2559 (2004), Abstract;
Peroxynitrite-mediated inactivation of heme oxygenases: R. Kinobe, et al.; BMC Pharmacol. 21, 4 (2004), Abstract; Full Text
New nitric oxide-releasing zwitterions derived from polyamines : J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993),
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects: C.M. Maragos, et al.; J. Med. Chem. 34, 3242 (1991), Abstract;
DNA deaminating ability and genotoxicity of nitric oxide and its progenitors: D.A. Wink, et al.; Science 254, 1001 (1991), Abstract;
The Reaction of Nitrogen(II) Oxide with Various Primary and Secondary Amines: R.S. Drago & B.R. Karstetter; JACS 83, 1819 (1961),
The Reaction of Nitrogen(II) Oxide with Diethylamine: R.S. Drago & F.E. Paulik; JACS 82, 96 (1960),

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