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Diacylglycerol Kinase Inhibitor II (R59 949)

Potentiates PKC activity
ALX-430-028-M005 5 mg 118.00 USD
ALX-430-028-M025 25 mg 354.00 USD
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Replaces Prod. #: BML-EI202

Inhibitor of diacylglycerol kinase in intact cells (IC50=0.12µM) and in isolated membranes (IC50=0.3µM). More potent analog of R59 022 (Prod. No. ALX-430-027). Useful for elucidating roles of protein kinase C (PKC).

Product Specification

Alternative Name:3-[2-[4-[bis(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Purity:≥98% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in dichloromethane, ethyl acetate, tetrahydro-furan, DMSO (33mg/ml) or dimethyl formamide; almost insoluble in water.
Long Term Storage:+4°C
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Product Literature References

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth: P. Depeille, et al.; Nat. Cell. Biol. 17, 804 (2015), Application(s): Cell Culture, Abstract;
The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy: J.S. You, et al.; J. Biol. Chem. 289, 1551 (2014), Abstract; Full Text
Lysophosphatidic acid acyltransferase beta regulates mTOR signaling: M.A. Blaskovich, et al.; PLoS One 8, e78632 (2013), Application(s):MiaPaCa2 cells treatment, Abstract; Full Text
The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R 59 949: D. de Chaffoy de Courcelles, et al.; J. Biol. Chem. 264, 3274 (1989), Abstract; Full Text
R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet: D. de Chaffoy de Courcelles, et al.; J. Biol. Chem. 260, 15762 (1985), Abstract; Full Text

Related Products

Diacylglycerol Kinase Inhibitor I (R59 022) 

Potentiates PKC activity
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ALX-430-027-M005 5 mg 90.00 USD
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