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Diacylglycerol Kinase Inhibitor I (R59 022)

Potentiates PKC activity
ALX-430-027-M005 5 mg 90.00 USD
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Replaces Prod. #: BML-EI136

Potentiates the activity of protein kinase C (PKC) by inhibiting the diacylglycerol metabolism. Inhibits diacylglycerol kinase without affecting phosphodiesterase or phosphatidyl inositol kinase. It inhibits human platelet DAG kinase in intact cells (IC50=3.6μM) and in isolated membranes (IC50=6.7μM).

Product Specification

Alternative Name:6-[2-(4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl)ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidine-5-one
Appearance:Yellow powder.
Solubility:Soluble in DMSO, THF or DMF. Insoluble in water.
Long Term Storage:+4°C
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Product Literature References

R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet: D. de Chaffoy de Courcelles, et al.; J. Biol. Chem. 260, 15762 (1985), Abstract; Full Text

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