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PAPA NONOate

Nitric oxide donor
 
ALX-430-016-M005 5 mg 33.00 USD
 
ALX-430-016-M025 25 mg 96.00 USD
 
ALX-430-016-5005 5x5 mg 133.00 USD
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Nitric oxide (NO) donor. The half-life time of PAPA NONOate is 76.6 min. at 22°C in 0.1M phosphate buffer, pH 7.4. Decomposition of NONOates is nearly instantaneous at pH 5.0.

Product Specification

Alternative Name:PAPA/NO, NOC-15, (Z)-1-[N-(3-Ammoniopropyl)-N-(n-propyl)amino]diazen-1-ium-1,2-diolate
 
Formula:C6H16N4O2
 
MW:176.2
 
CAS:146672-58-4
 
Purity:≥97%
 
Identity:Determined by NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water or methanol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Relatively stable in alkaline solution.
 
Handling:Protect from moisture. Keep under inert gas.
 
ALX-430-016
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ALX-430-016

Product Literature References

Characterisation and comparison of temporal release profiles of nitric oxide generating donors: S.A. Bradley & J.R. Steinert; J. Neurosci. Methods 245, 116 (2015), Application(s): Nitric Oxide Donor, Abstract;
Dual effects of nitric oxide on the large conductance calcium-activated potassium channels of rat brain: J.E. Lee, et al.; J. Biochem. Mol. Biol. 39, 91 (2006), Abstract;
Role of nitric oxide-induced mtDNA damage in mitochondrial dysfunction and apoptosis: L.I. Rachek, et al.; Free Radic. Biol. Med. 40, 754 (2006), Abstract;
Nitric oxide donors alter cardiomyocyte cytokine secretion and cardiac function: D.L. Maass, et al.; Crit. Care Med. 33, 2794 (2005), Abstract;
Nitric oxide inhibits cAMP-dependent CFTR trafficking in intestinal epithelial cells: A.C. Skinn & W.K. MacNaughton; Am. J. Physiol. Gastrointest. Liver Physiol. 289, G739 (2005), Abstract; Full Text
Position in cell cycle controls the sensitivity of colon cancer cells to nitric oxide-dependent programmed cell death: A. Jarry, et al.; Cancer Res. 64, 4227 (2004), Abstract;
Effects of redox-related congeners of NO on apoptosis and caspase-3 activity: J. Haendeler, et al.; Nitric Oxide 1, 282 (1997), Abstract;
New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993),

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