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Spermine NONOate

Nitric oxide donor
ALX-430-013-M005 5 mg 35.00 USD
ALX-430-013-M025 25 mg 106.00 USD
ALX-430-013-5005 5x5 mg 148.00 USD
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Nitric oxide (NO) donor. A convenient reagent for preparing aqueous solutions of NO.

Product Specification

Alternative Name:SPER/NO, (Z)-1-{N-[3-Aminopropyl]-N-[4-(3-aminopropylammonio)butyl]-amino}-diazen-1-ium-1,2-diolate
Purity:≥97% (NMR)
Appearance:White to off-white crystalline solid.
Solubility:Soluble in water, methanol or 100% ethanol.
Shipping:Shipped on Blue Ice
Long Term Storage:-80°C
Use/Stability:Relatively stable in alkaline solution.
Handling:Protect from light and oxygen. Keep under inert gas. Hygroscopic.
Technical Info/Product Notes:Product dissociates to the free amine and nitric oxide in a pH dependent manner following first order kinetics. Alkaline solutions of NONOates (in 0.01M NaOH) are stable and can be stored at 0°C for 24 hours. To initiate the release of nitric oxide add alkaline solution of Spermine NONOate to excess buffer of pH 7.0 - 7.4. Relatively high concentrated solutions can be prepared for further dilution. Half life in 0.1M phosphate buffer (pH 7.4) at 37 C is t½ (min.) 39. Decomposition is nearly instantaneous at pH 5.
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Product Literature References

Subtle reproductive impairment through nitric oxide-mediated mechanisms in sea urchins from an area affected by harmful algal blooms: O. Migliaccio, et al.; Sci. Rep. 6, 26086 (2016), Application(s): Cell culture, Abstract; Full Text
Excessive nitric oxide attenuates leptin-mediated signal transducer and activator of transcription 3 activation: E.H. Jang, et al.; Life Sci. 80, 609 (2007), Abstract;
Inflammatory cytokines induce MAdCAM-1 in murine hepatic endothelial cells and mediate alpha-4 beta-7 integrin dependent lymphocyte endothelial adhesion in vitro: T. Ando, et al.; BMC Physiol. 7, 10 (2007), Abstract; Full Text
Effects of antioxidants and NO on TNF-alpha-induced adhesion molecule expression in human pulmonary microvascular endothelial cells: M.Z. Jiang, et al.; Respir. Med. 99, 580 (2005), Abstract;
Effects of antioxidant and nitric oxide on chemokine production in TNF-alpha-stimulated human dermal microvascular endothelial cells: M.Z. Jiang, et al.; Free Radic. Res. 38, 473 (2004), Abstract;
Extracellular nitric oxide release mediates soluble guanylate cyclase-independent vasodilator action of spermine NONOate: comparison with other nitric oxide donors in isolated rat femoral arteries: M.R. Miller, et al.; J. Cardiovasc. Pharmacol. 43, 440 (2004), Abstract;
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro 15, 181 (2001), Abstract;
In vitro cytotoxicity of the nitric oxide donor, S-nitroso-N-acetyl-penicillamine, towards cells from human oral tissue: H. Babich, et al.; Pharmacol. Toxicol. 84, 218 (1999), Abstract;
New nitric oxide-releasing zwitterions derived from polyamines : J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993),
Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release: C.M. Maragos, et al.; Cancer Res. 53, 564 (1993), Abstract;
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects: C.M. Maragos, et al.; J. Med. Chem. 34, 3242 (1991), Abstract;

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