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GEA 3162

Nitric oxide donor
 
ALX-430-004-M010 10 mg 72.00 USD
 
ALX-430-004-M050 50 mg 289.00 USD
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Water soluble nitric oxide donor and potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). Stimulates cGMP production in platelets, granulocytes and polymorphonuclear leukocytes. Vasodepressant.

Product Specification

Alternative Name:1,2,3,4-Oxatriazolium, 5-amino-3-(3,4-dichlorophenyl)-, chloride
 
Formula:C7H4Cl2N4O . HCl
 
MW:231.0 . 36.5
 
CAS:144575-47-3
 
Purity:≥97% (TLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in water, methanol or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from oxygen. Use fresh solutions.
 
430-004
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430-004

Product Literature References

Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes: S. Ljubicic, et al; Cell Rep. 10, 497 (2015), Application(s): Cell Culture, Abstract;
GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation: M.F. Hsu, et al.; Eur. J. Pharmacol. 535, 43 (2006), Abstract;
Flow cytometric evaluation of human neutrophil apoptosis during nitric oxide generation in vitro: the role of exogenous antioxidants: Z. Sulowska, et al.; Mediators Inflamm. 2005, 81 (2005), Abstract; Full Text
GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism: E.L. Taylor, et al.; Br. J. Pharmacol. 143, 179 (2004), Abstract;
Ca(2+) entry activated by S-nitrosylation. Relationship to store-operated ca(2+) entry: H.T. Ma, et al.; J. Biol. Chem. 274, 35318 (1999), Abstract; Full Text
Mesoionic oxatriazole derivatives-a new group of NO-donors: G. Karup, et al.; Pol. J. Pharmacol. 46, 541 (1994), Abstract;
Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein: U. Malo-Ranta, et al.; FEBS Lett. 337, 179 (1994), Abstract;
Pharmacology of mesoionic oxatriazole derivatives in blood, cardiovascular and respiratory systems: T. Corell, et al.; Pol. J. Pharmacol. 46, 553 (1994), Abstract;
Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions: E. Moilanen, et al.; Br. J. Pharmacol. 109, 852 (1993), Abstract;
Scavenging of superoxide anions by nitric oxide donors: J. Robak, et al.; Pharmacol. Res. 25 S2, 355 (1992),

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