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Molsidomine

NO releasing vasodilator
 
ALX-430-003-M050 50 mg 7.00 USD
 
ALX-430-003-M250 250 mg 30.00 USD
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Replaces Prod. #: BML-CN244

Long acting antianginal drug that is enzymatically converted in the liver to yield the active metabolite SIN-1 (Prod. No. BML-CN245). NO releasing vasodilator.

Product Specification

Alternative Name:N-(Ethoxycarbonyl)-3-(4-morpholinyl)sydnoneimine, Morsidomine, SIN-10
 
Formula:C9H14N4O4
 
MW:242.2
 
CAS:25717-80-0
 
MI:14: 6234
 
Purity:≥98% (TLC)
 
Identity:Determined by NMR.
 
Appearance:White solid.
 
Solubility:Soluble in methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
430-003
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430-003

Product Literature References

Nitric oxide donor molsidomine attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801: N. Pitsikas, et al.; J. Neurosci. Res. 84, 299 (2006), Abstract;
Long-term treatment with the NO-donor molsidomine reduces circulating ICAM-1 levels in patients with stable angina: C. Van Hove, et al.; Atherosclerosis 180, 399 (2005), Abstract;
Molsidomine, a nitric oxide donor and L-arginine protects against rhabdomyolysis-induced myoglobinuric acute renal failure: V. Chander & K. Chopra; Biochim. Biophys. Acta 1723, 208 (2005), Abstract;
Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats: A. Rodriguez-Pena, et al.; Am. J. Transplant. 4, 1605 (2004), Abstract;
Molsidomine: alternative approaches to treat myocardial ischemia: R.-E. Nitz & V.B. Fiedler; Pharmacotherapy 7, 28 (1987), Abstract;
H.U. Daeniker & J. Druey; Helv. Chim. Acta 45, 2426 (1962),

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SIN-1A/γCD Complex 

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3-Morpholinosydnonimine 

Releases NO and superoxide anion under physiological conditions
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