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Purmorphamine

Smoothened activator
 
ALX-420-045-M001 1 mg 54.00 USD
 
ALX-420-045-M005 5 mg 181.00 USD
 
ALX-420-045-M025 25 mg 595.00 USD
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Cell permeable purine compound. Induces osteoblast differentiation. Agonist of smoothened by activation of the Hedgehog (Hh) pathway. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Binds to and activates 7-transmembrane receptor of Hh.

Product Specification

Alternative Name:2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
 
Formula:C31H32N6O2
 
MW:520.6
 
CAS:483367-10-8
 
Purity:≥98% (HPLC)
 
Appearance:Off-white to beige solid.
 
Solubility:Soluble in DMSO (10mM).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
 
Handling:Protect from light. After reconstitution, prepare aliquots and store at -20°C.
 
420-045
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420-045

Product Literature References

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein: M. Ehrlich, et al.; Stem Cell Reports 5, 83 (2015), Application(s): Cell Culture, Abstract; Full Text
Lung Fibroblasts Share Mesenchymal Stem Cell Features Which Are Altered in Chronic Obstructive Pulmonary Disease via the Overactivation of the Hedgehog Signaling Pathway: F. Figeac, et al.; PLoS One 10, e0121579 (2015), Application(s): Cell Culture, Abstract; Full Text
Purmorphamine activates the Hedgehog pathway by targeting Smoothened: S. Sinha & J.K. Chen; Nat. Chem. Biol. 2, 29 (2006), Abstract;
Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells: M.M. Beloti, et al.; Cell Biol. Int. 29, 537 (2005), Abstract;
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway: X. Wu, et al.; Chem. Biol. 11, 1229 (2004), Abstract;
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells: X. Wu, et al.; JACS 124, 14520 (2002), Abstract;

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