Antitumor and antiangiogenic compound. DNA alkylating agent. Induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA. Inactivates DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway. Chemotherapeutic agent. Modifies drug resistance.
Product Details
Alternative Name: | 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one |
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Formula: | C6H6N6O2 |
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MW: | 194.2 |
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CAS: | 85622-93-1 |
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MI: | 14: 9139 |
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RTECS: | NJ5927050 |
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Purity: | ≥98% (HPLC) |
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Appearance: | White to off-white crystalline powder. |
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Solubility: | Soluble in DMSO; slightly soluble in water. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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