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WS-12

TRMP8 agonist
 
ALX-420-041-M001 1 mg 30.00 USD
 
ALX-420-041-M005 5 mg 90.00 USD
 
ALX-420-041-M025 25 mg 310.00 USD
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Cooling agent. High-affinity TRPM8 (cold menthol receptor 1; CMR1) agonist. Has an EC50 value ~2'000 times lower than that of (-)-menthol (Prod. No. ALX-420-042).

Product Specification

Alternative Name:(2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide
 
Formula:C18H27NO2
 
MW:289.4
 
CAS:68489-09-8
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in 100% ethanol, methanol, ethyl acetate, , dimethyl formamide or acetonitrile; insoluble in water or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
420-041
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420-041

Product Literature References

Characterisation of TRPM8 as a pharmacophore receptor: M. Bodding, et al.; Cell Calcium 42, 618 (2007), Abstract;
Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators: B. Beck, et al.; Cell Calcium 41, 285 (2007), Abstract;

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Icilin 

TRPM8 activator
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