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Imiquimod

TLR7 ligand
 
ALX-420-039-M100 100 mg 69.00 USD
 
ALX-420-039-M250 250 mg 152.00 USD
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Replaces Prod. #: BML-CT106

Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.

Product Specification

Alternative Name:1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, R-837
 
Formula:C14H16N4
 
MW:240.3
 
CAS:99011-02-6
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
 
Handling:After reconstitution, prepare aliquots and store at -20°C.
 
Technical Info/Product Notes:Stimulation of TLR7 can be achieved with 1-10µg/ml of the compound for 6 to 24 hours.
 
420-039
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Product Literature References

TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons: L. Maatouk, et al.; Nat. Commun. 9, 2450 (2018), Abstract; Full Text
Poly (I: C) and imiquimod induced immune responses and their effects on the survival of olive flounder (Paralichthys olivaceus) from viral haemorrhagic septicaemia: S. Avunje, et al.; Fish Shellfish Immunol. 17, 338 (2017), Abstract;
Tamoxifen downregulates MxA expression by suppressing TLR7 expression in PBMCs of males infected with HCV: I.O. Fawzy, et al.; J. Med. Virol. 86, 1113 (2014), Abstract;
Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation: T. Hirai, et al.; J. Immunol. 190, 4805 (2013), Abstract;
Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in peripheral blood mononuclear cells of patients infected with hepatitis C virus: S.S. Tayel, et al.; Arch. Virol. 158, 1755 (2013), Abstract;
Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands: C. Sekine, et al.; Int. Immunol. 21, 295 (2009), Abstract;
Imiquimod as an antiangiogenic agent: V.W. Li, et al.; J. Drugs Dermatol. 4, 708 (2005), Abstract;
Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis: S. Majewski, et al.; Int. J. Dermatol. 44, 14 (2005), Abstract;
In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases: C. Hesling, et al.; Br. J. Dermatol. 150, 761 (2004), Abstract;
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway: H. Hemmi, et al.; Nat. Immunol. 3, 196 (2002), Abstract;
Imiquimod applied topically: a novel immune response modifier and new class of drug: R.L. Miller, et al.; Int. J. Immunopharmacol. 21, 1 (1999), Abstract;

General Literature References

Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis: S. Majewski, et al.; Int. J. Dermatol. 44, 14 (2005), Abstract;

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