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GW501516

PPARδ agonist
 
ALX-420-032-M001 1 mg 74.00 USD
 
ALX-420-032-M005 5 mg 183.00 USD
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GW501516 is a specific agonist for PPARδ (EC50=1.1nM) with a 1'000-fold selectivity over the other human subtypes.

Product Specification

Formula:C21H18F3NO3S2
 
MW:453.5
 
CAS:317318-70-0
 
Purity:≥98% (HPLC)
 
Identity:Identity determined by 1H-NMR and 13C-NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (50mg/ml), dimethyl formamide (25mg/ml), 100% ethanol (12mg/ml) or methanol (50mg/ml); slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
420-032
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420-032

Product Literature References

Ligand-activated PPARδ upregulates α-smooth muscle actin expression in human dermal fibroblasts: a potential role for PPARδ in wound healing: S.A. Ham, et al.; J. Dermatol. Sci. 80, 186 (2015), Application(s): Cell Culture, Abstract;
PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation: E. Barroso, et al.; Biochim. Biophys. Acta 1852, 1049 (2015), Application(s): Cell Culture, Abstract;
PPARδ modulates oxLDL-induced apoptosis of vascular smooth muscle cells through a TGF-β/FAK signaling axis: J.S. Hwang, et al.; Int. J. Biochem. Cell. Biol. 62, 54 (2015), Application(s): Cell Culture, Abstract;
Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells: T. Coll, et al.; Endocrinology 151, 1560 (2010), Abstract;
Activation of PPARdelta promotes mitochondrial energy metabolism and decreases basal insulin secretion in palmitate-treated beta-cells: L. Jiang, et al.; Mol. Cell. Biol. 343, 249 (2010), Abstract;
Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells: P. Sertznig, et al.; Anticancer Res. 29, 3647 (2009), Abstract;
Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination: A. Defaux, et al.; J. Neuroinflammation 6, 15 (2009), Abstract;
Determination of the critical amino acids involved in the peroxisome proliferator-activated receptor (PPAR) delta selectivity of phenylpropanoic acid-derived agonists: J. Kasuga, et al.; Chem. Med. Chem. 3, 1662 (2008), Abstract;
A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta: Z.L. Wei & A.P. Kozikowski; J. Org. Chem. 68, 9116 (2003), Abstract;
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)-synthesis and biological activity: M.L. Sznaidman, et al.; Bioorg. Med. Chem. Lett. 13, 1517 (2003), Abstract;
Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism: A.J. Gilde, et al.; Circ. Res. 92, 518 (2003), Abstract;
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity: Y.X. Wang, et al.; Cell 113, 159 (2003), Abstract;
PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells: B. Glinghammar, et al.; BBRC 308, 361 (2003), Abstract;
The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells: U. Dressel, et al.; Mol. Endocrinol. 17, 2477 (2003), Abstract;
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport: W.R. Oliver, Jr., et al.; PNAS 98, 5306 (2001), Abstract; Full Text

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