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GW1929

PPARγ agonist
 
ALX-420-029-M001 1 mg 93.00 USD
 
ALX-420-029-M005 5 mg 434.00 USD
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Potent (<10nM) and subtype-selective (>1'000-fold) PPARγ agonist which does not contain a thiazolidinedione moiety. The glucose-lowering effect of GW1929 in rats is 100-fold more potent than that of troglitazone (Prod. No. BML-GR210).

Product Specification

Alternative Name:N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist, (2S)-((2-Benzoylphenyl)amino-3-[4-[2-(methylpyridin-2-ylamino)ethoxy]phenyl)propionic acid
 
Formula:C30H29N3O4
 
MW:495.6
 
CAS:196808-24-9
 
Purity:≥97% (HPLC)
 
Appearance:Off-white to yellow crystalline solid.
 
Solubility:Soluble in DMSO or methanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
420-029
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Product Literature References

15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications: T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab. 90, 3534 (2005), Abstract; Full Text
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929: W.C. Huang, et al.; Exp. Cell Res. 277, 192 (2002), Abstract;
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents: B.R. Henke, et al.; J. Med. Chem. 41, 5020 (1998), Abstract;

Related Products

Troglitazone 

PPAR ligand
97322-87-7, Synthetic., ≥98% (HPLC) | Print as PDF
 
BML-GR210-0005 5 mg 108.00 USD
 
BML-GR210-0025 25 mg 445.00 USD
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