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(-)-Indolactam V

PKC activator
 
ALX-420-011-C300 300 µg 175.00 USD
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Moderately potent indolactam activator of protein kinase C (PKC). Increases cytoplasmic mRNAs. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells to pancreatic progenitor cells.

Product Specification

Formula:C17H23N3O2
 
MW:301.4
 
CAS:90365-57-4
 
RTECS:UY8547000
 
Purity:≥95% (1H-NMR)
 
Identity:May contain traces of (+)-Indolactam V.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
ALX-420-011
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ALX-420-011

Product Literature References

Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay: H.L. Shieh, et al.; Mol. Carcinogen. 12, 166 (1995), Abstract;
Interleukin-4 signals regulating CD23 gene expression in human B cells: protein kinase C-independent signaling pathways: C.E. Lee, et al.; Cell Immunol. 146, 171 (1993), Abstract;
(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells: J. Heikkilä & K. Akerman; BBRC 162, 1207 (1989), Abstract;
Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin: H. Fujiki, et al.; Gann 75, 866 (1984), Abstract;

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