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Compound 48/80 . trihydrochloride

G protein activator
ALX-420-008-M100 100 mg 92.00 USD
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Replaces Prod. #: BML-EI179

Compound 48/80 is an oligomeric mixture of condensation products of N-methyl-p-methoxyphenethylamine and formaldehyde. It activates G proteins by a mechanism analogous to that of mastoparan. It inhibits calmodulin and human platelet PLC and exhibits a concentration dependent biphasic modulation of human platelet PLA2.

Product Specification

Formula:C32H46N3O3 . 3HCl
MW:520.7 . 109.4
Identity:Determined by 1H-NMR.
Appearance:White to off-white solid.
Solubility:Soluble in water (100mg/ml).
Long Term Storage:-20°C
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
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Product Literature References

In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis: R. Pagliarini, et al.; Cell. Rep. 15, 2292 (2016), Application(s): Determined histamine-mediated skin permeability, Abstract;
Anti-inflammatory and antinociceptive activity of ouabain in mice: D.I. de Vasconcelos, et al.; Mediators Inflamm. 2011, 912925 (2011), Abstract; Full Text
Activation of the Na+/K(+)-pump in rat peritoneal mast cells following histamine release: a possible role in cell recovery: T. Knudsen, et al.; Br. J. Pharmacol. 108, 120 (1993), Abstract;
Eclosion hormone activates phosphatidylinositol hydrolysis in silkworm abdominal ganglia during adult metamorphosis: Y. Shibanaka, et al.; Eur. J. Biochem. 211, 427 (1993), Abstract;
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol. 226, 87 (1992), Abstract;
Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells: S. Akiba, et al.; Biochem. Pharmacol. 44, 45 (1992), Abstract;
Phosphorylation of smg p21B in rat peritoneal mast cells in association with histamine release inhibition by dibutyryl-cAMP: K. Izushi, et al.; FEBS Lett. 314, 241 (1992), Abstract;
Activation of bovine rod outer segment phosphatidylinositol-4,5- bisphosphate phospholipase C by calmodulin antagonists does not depend on calmodulin: B.D. Gehm, et al.; Biochemistry 30, 11302 (1991), Abstract;
Direct activation of GTP-binding regulatory proteins (G-proteins) by substance P and compound 48/80: M. Mousli et al.; FEBS Lett. 259, 260 (1990), Abstract;
Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity: T. Higashijima et al.; J. Biol. Chem. 265, 14176 (1990), Abstract;
Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet: C. Bronner et al.; Biochim. Biophys. Acta 920, 301 (1987), Abstract;
Comparison of the calmodulin antagonists compound 48/80 and calmidazolium: K. Gietzen; Biochem. J. 216, 611 (1983), Abstract;
Compound 48/80 is a selective and powerful inhibitor of calmodulin-regulated functions: K. Gietzen et al.; Biochim. Biophys. Acta 736, 109 (1983), Abstract;

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