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United States 

GSNO

Nitric oxide donor
 
ALX-420-002-M025 25 mg 87.00 USD
 
ALX-420-002-M100 100 mg 260.00 USD
 
Replaces Prod. #: BML-CN253

NO donor which spontaneously releases NO under physiological conditions. Half-life of 159 hours under physiological conditions. Selectively inhibits platelet activation and displays cardioprotective effects. Inhibits NF-κB activation. Inhibits endothelial cell proliferation and induces apoptosis in T cells.

Product Specification

Alternative Name:S-Nitroso-L-glutathione, N-(N-L-γ-Glutamyl-S-nitroso-L-cysteinyl)-glycine
 
Formula:C10H16N4O7S
 
MW:336.3
 
CAS:57564-91-7
 
Purity:≥98% (HPLC)
 
Appearance:Crystalline solid.
 
Solubility:Soluble in water (25mg/ml),  DMSO (20mg/ml) or PBS; sparingly soluble in 100% ethanol, methanol or dimethyl formamide.
 
Long Term Storage:-20°C
 
ALX-420-002
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ALX-420-002

Product Literature References

GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions: R. Prasad, et al.; Glia 55, 65 (2007), Abstract;
Mechanisms of cystic fibrosis transmembrane conductance regulator activation by S-nitrosoglutathione: L. Chen, et al.; J. Biol. Chem. 281, 9190 (2006), Abstract;
Modulation of glucose uptake in adipose tissue by nitric oxide-generating compounds: D. McGrowder, et al.; J. Biosci. 31, 347 (2006), Abstract;
Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner: M. C. Gonzalez-Leon, et al.; J. Endotoxin Res. 12, 296 (2006), Abstract;
Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells: H. K. Jeon, et al.; Cell. Biol. Toxicol. 21, 115 (2005), Abstract;
Protection from experimental asthma by an endogenous bronchodilator: G. Que, et al.; Science 308, 1618 (2005), Abstract;
Redox regulation of PTEN by S-nitrosothiols: C.X. Yu, et al.; Mol. Pharmacol. 68, 847 (2005), Abstract; Full Text
S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke: M. Khan, et. al.; J. Cereb. Blood Flow Metab. 25, 177 (2005), Abstract;
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem. 275, 13613 (2000), Abstract; Full Text
The dual role of S-nitrosoglutathione (GSNO) during thymocyte apoptosis: K. Sandau & B. Brune; Cell Signal 8, 173 (1996), Abstract;
Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B: H.B. Peng et al.; J. Biol. Chem. 270, 14214 (1995), Abstract;
Nitric oxide inhibition of endothelial cell mitogenesis and proliferation: R. Sarkar et al.; Surgery 118, 274 (1995), Abstract;
Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells: H.B. Peng et al.; J. Biol. Chem. 270, 17050 (1995), Abstract;
S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide: E.A. Konorev et al.; J. Pharmacol. Exp. Ther. 274, 200 (1995), Abstract;
Effects of S-nitroso-glutathione in the human forearm circulation: evidence for selective inhibition of platelet activation: A.J. de Belder et al.; Cardiovasc Res 28, 691 (1994), Abstract;
Biological activity of S-nitrosothiols: the role of nitric oxide: W.R. Mathews & S.W. Kerr; J. Pharmacol. Exp. Ther. 267, 1529 (1993), Abstract;
An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus: A. Gibson, et al.; Br. J. Pharmacol. 107, 715 (1992), Abstract;
S-nitroso-glutathione inhibits platelet activation in vitro and in vivo: M.W. Radomski, et al.; Br. J. Pharmacol. 107, 745 (1992), Abstract;

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