Glycoside-derivative of podophyllotoxin. Has cytostatic effect. Inhibits topoisomerase II. Induces apoptosis.
Product Details
| Alternative Name: | (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 4’-Demethylepipodophyllotoxin-β-D-thenylidine glucoside |
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| Formula: | C32H32O13S |
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| MW: | 656.7 |
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| Source: | Semisynthetic derivative of podophyllotoxin. |
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| CAS: | 29767-20-2 |
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| MI: | 14: 9145 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by IR. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in acetone or dimethyl formamide; slightly soluble in methanol; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II: M. Liu, et al.; J. Biol. Chem.
290, 14418 (2015),
Application(s): Cell Culture, Injection into mice,
Abstract;
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Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma: J. Li, et al.; World J. Surg. Oncol.
4, 41 (2006),
Abstract;
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Topoisomerase II as a target of VM-26 and 4’-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells: S. de Jong, et al.; Cancer Res.
53, 1064 (1993),
Abstract;
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Human cytochrome P450 metabolism of teniposide and etoposide: M.V. Relling, et al.; J. Pharmacol. Exp. Ther.
261, 491 (1992),
Abstract;
Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage: W. Ross, et al.; Cancer Res.
44, 5857 (1984),
Abstract;
Full Text
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