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Cyclophosphamide . monohydrate

DNA alkylating agent
 
ALX-400-051-G001 1 g 35.00 USD
 
ALX-400-051-G005 5 g 77.00 USD
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Alkylates DNA, forming DNA-DNA cross-links that result in inhibition of DNA synthesis and cell death. Interestingly the repair enzyme O6-alkylguanine-DNA alkyltransferase, long thought to be involved with resistance to methylating and chloroethylating agents, may also contribute to resistance to the cytotoxic and mutagenic effects of cyclophosphamide.

Product Specification

Alternative Name:2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide, Cytoxan
 
Formula:C7H15CI2N2O2P . H2O
 
MW:261.1 . 18.0
 
Source:Synthetic.
 
CAS:6055-19-2
 
MI:14: 2747
 
RTECS:RP6157750
 
Purity:≥97% (HPLC)
 
Identity:Determined by IR and UV.
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in water; slightly soluble in 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
400-051
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400-051

Product Literature References

Protective effect of curcumin and chlorophyllin against DNA mutation induced by cyclophosphamide or benzo[a]pyrene: M.A. Ibrahim, et al.; Z. Naturforsch. 62, 215 (2007), Abstract;
Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide: Z. Wang, et al.; Basic Clin. Pharmacol. Toxicol. 98, 411 (2006), Abstract;
Mechanisms of resistance to the toxicity of cyclophosphamide: M.P. Gamcsik, et al.; Curr. Pharm. Des. 5, 587 (1999), Abstract;
An overview of cyclophosphamide and ifosfamide pharmacology: R.A. Fleming; Pharmacotherapy 17, 146S (1997), Abstract;
Induction of apoptosis in murine tumors by cyclophosphamide: R.E. Meyn, et al.; Cancer Chemother. Pharmacol. 33, 410 (1994), Abstract;

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