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Mitoxantrone . dihydrochloride

DNA intercalator and Topoisomerase II inhibitor
 
ALX-400-050-M010 10 mg 33.00 USD
 
ALX-400-050-M050 50 mg 61.00 USD
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Antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Has been shown to be an inhibitor of DNA methylation.

Product Specification

Alternative Name:1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione . dihydrochloride
 
Formula:C22H28N4O6 . 2HCl
 
MW:444.5 . 73.0
 
Source:Synthetic.
 
CAS:70476-82-3
 
MI:14: 6217
 
RTECS:CB5748500
 
Purity:≥97% (Assay)
 
Identity:Determined by IR and MS.
 
Appearance:Blue to black crystalline solid.
 
Solubility:Soluble in water; slightly soluble in 100% ethanol or methanol; insoluble in acetonitrile or acetone.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
400-050
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400-050

Product Literature References

Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance-Associated Protein 2 and Breast Cancer Resistance Protein: C.P. Yu, et al.; J. Pharm. Sci. 105, 343 (2016), Application(s): Used as a probe substrate for evaluating the activity of BCRP, Abstract;
A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al.; J. Biol. Chem. 279, 18814 (2004), Abstract; Full Text
A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002), Abstract; Full Text
Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells: A. Skladanowski & J. Konopa; Br. J. Cancer 82, 1300 (2000), Abstract;
Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer: D. Faulds, et al.; Drugs 41, 400 (1991), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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