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Thimerosal

Antiseptic and antifungal agent
 
ALX-400-013-G005 5 g 77.00 USD
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Modulates thiol groups in biological systems, especially in those involving cAMP, Ca2+ and inositol phosphate. Causes a release of calcium from intracellular stores in many cells types. Has toxic effects on several cell types. Induces apoptosis in vitro.

Product Specification

Alternative Name:Ethyl mercurithiosalicylic acid . Na, Mercurothiolate
 
Formula:C9H9HgO2SNa
 
MW:404.8
 
CAS:54-64-8
 
MI:14: 9317
 
Purity:≥98% (Assay)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water (600mg/ml) or methanol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light.
 
ALX-400-013
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ALX-400-013

Product Literature References

Being on the track of thimerosal: A. Madi; Acta Microbiol. Immunol. Hung. 52, 95 (2005), Abstract;
Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction: G. Bultynck, et al.; Biochem. J. 381, 87 (2004), Abstract;
Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts: D. S. Baskin, et al.; Toxicol. Sci. 74, 361 (2003), Abstract;
Thimerosal: a versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent:: J.G. Elferink; Gen. Pharmacol. 33, 1 (1999), (Review), Abstract;
The effects of thimerosal on calcium uptake and inositol 1,4,5- trisphosphate-induced calcium release in cerebellar microsomes: L.G. Sayers, et al.; Biochem. J. 289, 883 (1993), Abstract;
Antibody to the inositol trisphosphate receptor blocks thimerosal- enhanced Ca(2+)-induced Ca2+ release and Ca2+ oscillations in hamster eggs: S. Miyazaki, et al.; FEBS Lett. 309, 180 (1992), Abstract;
Thimerosal causes calcium oscillations and sensitizes calcium-induced calcium release in unfertilized hamster eggs: K. Swann; FEBS Lett. 278, 175 (1991), Abstract;
Disulfide linkage of biotin identifies a 106-kDa Ca2+ release channel in sarcoplasmic reticulum: N.F. Zaidi, et al.; J. Biol. Chem. 264, 21737 (1989), Abstract; Full Text

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