Pterostilbene

[trans-3,5-Dimethoxy-4’-hydroxystilbene]



ALX-385-034-M025	25 mg	70.00 USD

ALX-385-034-M100	100 mg	130.00 USD

ALX-385-034-M500	500 mg	540.00 USD

Cell permeable natural methoxylated analog of resveratrol (Prod. No. ALX-270-125). Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Induces Autophagy. Very potent inhibitor of cytochrome P450 1A1 (CYP1A1) with K_i=0.57µM.Inhibits activator protein 1 (AP-1) and NF-κB activation. Moderately inhibits COX-1 and COX-2 (IC₅₀=19.8μM and 83.9μM).

Product Specification

Identity:	Identity determined by MS and ¹H-NMR.

Formula:	C₁₆H₁₆O₃

MW:	256.3

Purity:	≥98% (HPLC)

Appearance:	Off-white to light brown powder.

CAS:	537-42-8

MeltingPoint:	92.7-94.6°C

Source/Host:	Synthetic.

Solubility:	Soluble in DMSO (20mg/ml) or methanol; insoluble in water.

Shipping:	AMBIENT

Long Term Storage:	+4°C

Hazard:	IRRITANT.

Handling:	Protect from light and oxygen.

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Product Literature References

Antihyperglycemic activity of phenolics from Pterocarpus marsupium: M Manickam, et al.; J. Nat. Prod. 60, 609 (1997), Abstract;

Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol: A.M. Rimando, et al.; J. Agric. Food Chem. 50, 3453 (2002), Abstract;

Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents: M. Roberti, et al.; J. Med. Chem. 46, 3546 (2003), Abstract;

Antioxidant activity of hydroxystilbene derivatives in homogeneous solution: R. Amorati, et al.; J. Org. Chem. 69, 7101 (2004), Abstract;

Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma: P. Ferrer, et al.; Neoplasia 7, 37 (2005), Abstract; Full Text

Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters: A.M. Rimando, et al.; J. Agric. Food Chem. 53, 3403 (2005), Abstract;

Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers: S. Hougee, et al.; Planta Med. 71, 387 (2005), Abstract;

Effect of natural analogues of trans-resveratrol on cytochromes P4501A2 and 2E1 catalytic activities: R. Mikstacka, et al.; Xenobiotica 36, 269 (2006), Abstract;

Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats: L. Pari & M.A. Satheesh; Life Sci. 79, 641 (2006), Abstract;

Pharmacometrics of stilbenes: seguing towards the clinic: K.A. Roupe, et al.; Curr. Clin. Pharmacol. 1, 81 (2006), Abstract;

The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats: M. Amarnath Satheesh & L. Pari; J. Pharm. Pharmacol. 58, 1483 (2006), Abstract;

Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers: R. Mikstacka, et al.; Mol. Nutr. Food Res. 51, 517 (2007), Abstract;

Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma: P. Ferrer, et al.; J. Biol. Chem. 282, 2880 (2007), Abstract; Full Text

Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells: M.H. Pan, et al.; J. Agric. Food Chem. 55, 7777 (2007), Abstract;

Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats: N. Suh, et al.; Clin. Cancer Res. 13, 350 (2007), Abstract; Full Text

Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol: Z. Pan, et al.; BMC Med. Genomics 1, 7 (2008), Abstract; Full Text

In vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs: B. Billack, et al.; Cell. Mol. Biol. Lett. 13, 553 (2008), Abstract;

Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity: C.M. Remsberg, et al.; Phytother. Res. 22, 169 (2008), Abstract;

Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis: M. Cichocki, et al.; Mol. Nutr. Food Res. 52, S62 (2008), Abstract;

Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages: M.H. Pan, et al.; J. Agric. Food Chem. 56, 7502 (2008), Abstract;