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Wogonin

Anti-inflammatory and antioxidant
 
ALX-385-033-M005 5 mg 66.00 USD
 
ALX-385-033-M025 25 mg 246.00 USD
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Cell permeable and orally available flavonoid. Induces apoptosis in tumor cells but not in healthy cells by increasing peroxide production. Displays anti-inflammatory properties. Suppresses the release of nitric oxide (NO) by inducible nitric oxide synthase (iNOS; NOS II), PGE2 by cyclooxygenase-2 (COX-2), proinflammatory cytokines, MCP-1 gene expression and NF-κB activation. Antioxidant.

Product Specification

Alternative Name:5,7-Dihydroxy-8-methoxyflavone
 
Formula:C16H12O5
 
MW:284.3
 
CAS:632-85-9
 
RTECS:LK8331000
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White to yellow solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
385-033
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385-033

Product Literature References

Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLC{gamma}1- and Ca2+-dependent apoptosis: S. Baumann, et al.; Blood 111, 2354 (2007), Abstract;
Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action: R. Enomoto, et al.; J. Pharmacol. Sci. 104, 355 (2007), Abstract; Full Text
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis: S.C. Fas, et al.; Blood 108, 3700 (2006), Abstract; Full Text
Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells: S.O. Lee, et al.; BBRC 351, 118 (2006), Abstract;
Anti-inflammatory plant flavonoids and cellular action mechanisms: H.P. Kim, et al.; J. Pharmacol. Sci. 96, 229 (2004), Abstract; Full Text
Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1: Y.C. Chen, et al.; Arch. Toxicol. 76, 351 (2002), Abstract;
Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells: Y.L. Chang, et al.; Mol. Pharmacol. 60, 507 (2001), Abstract; Full Text
Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells: Y.S. Chi, et al.; Biochem. Pharmacol. 61, 1195 (2001), Abstract;
The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production: H. Kim, et al.; Neurosci. Lett. 309, 67 (2001), Abstract;
Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin: D.E. Shieh, et al.; Anticancer Res. 20, 2861 (2000), Abstract;
Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines: S. Ikemoto, et al.; Urology 55, 951 (2000), Abstract;
Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages: I. Wakabayashi; Pharmacol. Toxicol. 84, 288 (1999), Abstract;
The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin: C.C. Lin & D.E. Shieh; Am. J. Chin. Med. 24, 31 (1996), Abstract;

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