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(R,S)-Equol

Metabolite of daidzein
 
ALX-385-032-M005 5 mg 34.00 USD
 
ALX-385-032-M025 25 mg 149.00 USD
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Flavonoid. Racemic mixture. Urinary metabolite of daidzein. Inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. Shows positive effects on the incidence of prostate cancer and physiological changes after menopause. Functions as a DHT blocker. Preferentially activates estrogen receptor β (ERβ).

Product Specification

Alternative Name:(±)-Equol, 3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol, 4’,7-Dihydroxyisoflavane
 
Formula:C15H14O3
 
MW:242.3
 
CAS:531-95-3, 94105-90-5
 
MI:14: 3644
 
Purity:≥98% (HPLC, TLC)
 
Appearance:White to light yellow crystalline solid.
 
Solubility:Soluble in DMSO, methanol or 100% ethanol; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
385-032
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385-032

Product Literature References

Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway: N.J. Kang, et al.; J. Biol. Chem. 282, 32856 (2007), Abstract; Full Text
Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights: K.A. Jackman, et al.; Curr. Med. Chem. 14, 2824 (2007), Abstract;
High concordance of daidzein-metabolizing phenotypes in individuals measured 1 to 3 years apart: C.L. Frankenfeld, et al.; Br. J. Nutr. 94, 873 (2005), Abstract;
Comparisons of percent equol producers between prostate cancer patients and controls: case-controlled studies of isoflavones in Japanese, Korean and American residents: H. Akaza, et al.; Jpn. J. Clin. Oncol. 34, 86 (2004), Abstract; Full Text
Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback: T.D. Lund, et al.; Biol. Reprod. 70, 1188 (2004), Abstract; Full Text
Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women: C.L. Frankenfeld, et al.; Cancer Epidemiol. Biomarkers Prev. 13, 1156 (2004), Abstract; Full Text
Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells: S.O. Mueller, et al.; Toxicol. Sci. 80, 14 (2004), Abstract; Full Text

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