Anthocyanidin with antioxidant effect found in pigmented fruits and vegetables. Shown to inhibit angiogenesis and endothelial cell apoptosis by stimulating nitric oxide (NO) production. Inhibits solar radiation (UVB)-mediated oxidative stress, reducing DNA damage. Delphinidin induces necrosis in hepatocellular carcinoma cells with no caspase activation.
Product Details
| Formula: | C15H11ClO7 |
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| MW: | 338.7 |
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| CAS: | 528-53-0 |
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| RTECS: | DK1310000 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | Red to dark brown powder. |
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| Solubility: | Soluble in water or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Delphinidin Induces Necrosis in Hepatocellular Carcinoma Cells in the Presence of 3-Methyladenine, an Autophagy Inhibitor: R. Feng, et al.; J. Agric. Food Chem.
58, 3957 (2010),
Abstract;
Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis: F. Afaq, et al.; J. Invest. Dermatol.
127, 222 (2007),
Abstract;
Full Text
Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK: M.H. Oak, et al.; Br. J. Pharmacol.
149, 283 (2006),
Abstract;
Full Text
Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation: S. Lamy, et al.; Carcinogenesis
27, 989 (2006),
Abstract;
Full Text
DNA interaction with naturally occurring antioxidant flavonoids quercetin, kaempferol, and delphinidin: C.D. Kanakis, et al.; J. Biomol. Struct. Dyn.
22, 719 (2005),
Abstract;
Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines: M.C. Lazzè; Carcinogenesis
25, 1427 (2004),
Abstract;
Full Text
Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis: S. Martin, et al.; Br. J. Pharmacol.
139, 1095 (2003),
Abstract;
Full Text
