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Chemopreventive agent
ALX-385-012-M010 10 mg 40.00 USD
ALX-385-012-M050 50 mg 175.00 USD
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Antioxidant flavonoid. Has antitumor and chemopreventive properties. Anti-inflammatory. Inhibits NF-κB activation.
PIM1 kinase inhibitor IC50=0.78µM.

Product Specification

Alternative Name:3,3',4',5,5',7-Hexahydroxyflavone
MI:14: 6332
Purity:≥90% (HPLC)
Appearance:Light yellow-green crystals.
Solubility:Soluble in alcohol; slightly soluble in water (warm); insoluble in acetic acid.
Long Term Storage:-20°C
Handling:Protect from light.
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Product Literature References

A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity: B. LaFoya, et al.; PLoS One 14, e0210607 (2019), Abstract; Full Text
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase: S. Holder, et al.; Mol. Cancer Ther. 6, 163 (2007), Abstract;
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1: K.W. Lee, et al.; Carcinogenesis 28, 1918 (2007), Abstract;
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity: J. Lu, et al.; Cancer Res. 66, 4410 (2006), Abstract;
Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade: C.H. Ko, et al.; Biochem. Pharmacol. 69, 913 (2005), Abstract;
Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells: C.H. Ko, et al.; Mol. Cancer Ther. 4, 281 (2005), Abstract;
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro 15, 181 (2001), Abstract;
Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells: S. H. Tsai, et al.; J. Cell Biochem. 74, 606 (1999), Abstract;
Biological effects of myricetin: K. C. Ong & H. E. Khoo; Gen. Pharmacol. 29, 121 (1997), (Review), Abstract;
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radic. Biol. Med. 20, 933 (1996), (Review), Abstract;

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