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Streptochlorin

Apoptosis inducer. Angiogenesis inhibitor.
 
ALX-380-325-MC25 0.25 mg 82.00 USD
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Induces apoptosis through a reactive oxygen species (ROS) -mediated mitochondrial pathway. Has antiangiogenic and anticancer properties. Exhibits selective cytotoxicity against several cancer cell lines. Inhibits TNF-α-induced NF-κB activation and is a potent suppressor of angiogenesis in vitro.

Product Specification

Alternative Name:4-Chloro-5-(3-indolyl)oxazole, 3-(4-Chloro-5-oxazolyl)-1H-indole
 
Formula:C11H7ClN2O
 
MW:218.6
 
Source:Isolated from Streptomyces roseolilacinus NBRC 12815.
 
CAS:120191-51-7
 
Purity:≥95% (HPLC)
 
Appearance:Crystalline solid.
 
Solubility:Soluble in DMSO, hot methanol or water; insoluble in chloroform, ethyl acetate or hexane.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-325
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380-325

Product Literature References

Induction of apoptosis by streptochlorin isolated from Streptomyces sp. in human leukemic U937 cells.: C. Park, et al.; Toxicol. In Vitro 22, 1573 (2008), Abstract;
Streptochlorin isolated from Streptomyces sp. induces apoptosis in human hepatocarcinoma cells through a reactive oxygen species-mediated mitochondrial pathway: D. Y. Shin, et al.; J. Microbiol. Biotechnol. 18, 1862 (2008), Abstract;
Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110.: H. J. Shin, et al.; J. Microbiol. Biotechnol. 17, 1403 (2007), Abstract;
Streptochlorin, a marine natural product, inhibits NF-kappaB activation and suppresses angiogenesis in vitro.: I. K. Choi, et al.; J. Microbiol. Biotechnol. 17, 1338 (2007), Abstract;

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