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Macrosphelide A

Antifungal antibiotic
 
ALX-380-317-M001 1 mg 98.00 USD
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Macrolide antibiotic. Inhibitor of cell-cell adhesion molecule. Inhibits the growth of some ascomycetes, basidiomycetes, oomycetes and gram-positive bacteria, including the medically important Staphylococcus aureus (IC50 of ≤500 μg/ml in agar based tests). Ineffective against yeasts and gram-negative bacteria when tested at concentrations up to 700 μg/ml.

Product Specification

Alternative Name:(4S,7E,13E)-4α,10α,16α-Trimethyl-9β,15β-dihydroxy-1,5,11-trioxa-7,13-cyclohexadecadiene-2,6,12-trione
 
Formula:C16H22O8
 
MW:342.4
 
Source:Isolated from Paraconiothyrium sporulosum strain FO-5050.
 
CAS:172923-77-2
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in ethyl acetate, chloroform, dimethyl ether, DMSO or methanol; insoluble in water or hexane.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Scientific Background:Macrosphelide A was originally isolated from Microsphaeropsis sp.FO-5050 and Coniothyrium minitans. C. minitans is a mycoparasite of sclerotia of Sclerotinia sclerotiorum and Sclerotium cepivorum. Manufactured with courtesy strain from The Kitasato Institute.
 
alx-380-317
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Product Literature References

Antimicrobial activity of Coniothyrium minitans and its macrolide antibiotic macrosphelide A.: N. Tomprefa, et al.; J. Appl. Microbiol. 106, 2048 (2009), Abstract;
Production of macrosphelide A by the mycoparasite Coniothyrium minitans.: M.P. McQuilken, et al.; FEMS Microbiol. Lett. 219, 27 (2003), Abstract;
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. II. Physiochemical properties and structural elucidation.: S. Takamatsu, et al.; J. Antibiot. 49, 35 (1996), Abstract;
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities.: M. Hayashi, et al.; J. Antibiot. 48, 1435 (1995), Abstract;

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