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Beauvericin

Ionophore antibiotic
 
ALX-380-315-M001 1 mg 48.00 USD
 
ALX-380-315-M005 5 mg 145.00 USD
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Depsipeptide belonging to the enniatin family. Active against gram-positive bacteria and mycobacteria. Also active against insects and brine shrimp. The ion-complexing capability allows it to transport alkaline earth metal and alkali metal ions across cell membranes. Has been shown to potentiate the antifungal activity of miconazole.

Product Specification

Alternative Name:N-Methylcyclo(L-Phe-D-Hmb-N-methyl-L-Phe-D-Hmb-N-methyl-L-Phe-D-Hmb-), (3S,6R,9S,12R,15S,18R)-3,9,15-Tribenzyl-4,10,16-trimethyl-6,12,18-tripropan-2-yl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
 
Formula:C45H57N3O9
 
MW:784.0
 
Source:Isolated from Beauveria sp. FKI-1366.
 
CAS:26048-05-5
 
Purity:≥95% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in 100% ethanol, acetone, hexane or methanol (1mg/ml). Slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Scientific Background:Beauvericin occurs naturally in the fungus Beauveria bassiana.
 
Technical Info/Product Notes:Manufactured with courtesy strain from The Kitasato Institute.
 
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Product Literature References

Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res. 54, 87 (2015), Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis, Full Text
New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation and biological properties: T. Fukuda, et al.; J. Antibiot. 57, 110 (2004), Abstract;
New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. II. Structure elucidation: T. Fukuda, et al.; J. Antibiot. 57, 117 (2004), Abstract;
Actions of the antibiotic mycotoxins beauvericin and enniatin on mammalian tissue: K. Kouri, et al.; Forum Nutr. 56, 413 (2003), Abstract;
Beauvericin-induced channels in ventricular myocytes and liposomes: K. Kouri, et al.; Biochim. Biophys. Acta 1609, 203 (2003), Abstract;
Antimycobacterial and antiplasmodial cyclodepsipeptides from the insect pathogenic fungus Paecilomyces tenuipes BCC 1614: C. Nilanonta, et al.; Planta Med. 66, 756 (2000), Abstract;
Alkali ion transport through lipid bilayer membranes mediated by enniatin A and B and beauvericin: R. Benz; J. Membr. Biol. 43, 367 (1978), Abstract;
The structure of beauvericin, a new depsipeptide antibiotic toxic to Artemia salina: R.L. Hamill; Tetrahedron Lett. 10, 4255 (1969),

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