Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Hygromycin B (sterile-filtered solution in PBS)

Protein synthesis inhibitor
 
ALX-380-306-G001 1 g 105.00 USD
Do you need bulk/larger quantities?
 
Antibiotic. Inhibits growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Penetrates cells that have been permeabilized by virus infection, hence it can act as an effective antiviral agent.

Product Specification

Alternative Name:O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
 
Formula:C20H37N3O13
 
MW:527.5
 
Source:Isolated from Streptomyces hygroscopicus.
 
CAS:31282-04-9
 
MI:14: 4852
 
RTECS:WK2130000
 
Concentration:50mg/ml
 
Purity:≥90% (HPLC)
 
Purity Detail:Sterile filtered.
 
Appearance:Liquid. In PBS.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Working hygromycin solutions (≤2mg/ml) are stable for up to 1 month when stored at +4°C.
 
Handling:Protect from light.
 
380-306
Please mouse over
380-306

Product Literature References

Clr-a: A Novel Immune-Related C-Type Lectin-like Molecule Exclusively Expressed by Mouse Gut Epithelium: E. Rutkowski, et al.; J. Immunol. 198, 916 (2017), Abstract;
Hygromycin B inhibition of protein synthesis and ribosome biogenesis in Escherichia coli: S. M. McGaha & W. S. Champney; Antimicrob. Agents Chemother. 51, 591 (2007), Abstract;
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes: M. C. Ganoza & M. C. Kiel; Antimicrob. Agents Chemother. 45, 2813 (2001), Abstract;
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit:: D.E. Brodersen, et al.; Cell 103, 1143 (2000), Abstract;
Induction of p53-independent apoptosis by hygromycin B: suppression by Bcl-2 and adenovirus E1B 19-kDa protein: G. Chen, et al.; Exp. Cell Res. 221, 55 (1995), Abstract;
Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells: J. C. Lacal & L. Carrasco; Antimicrob. Agents Chemother. 24, 273 (1983), Abstract;
The Isolation of a Second Antibiotic from Streptomyces hygroscopicus: R. L. Mann & W. W. Bromer; J. Am. Chem. Soc. 80, 2714 (1958),

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,