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United States 

Curvularin

Inhibitor of iNOS expression
 
ALX-380-305-M001 1 mg 66.00 USD
 
ALX-380-305-M005 5 mg 265.00 USD
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Inhibits expression of inducible nitric oxide synthase (iNOS; NOSII). Has antifungal and antibiotic activity. Inhibits cell division. Similar to Curvulin.

Product Specification

Alternative Name:4,5,6,7,8,9-Hexahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione
 
Formula:C16H20O5
 
MW:292.3
 
CAS:10140-70-2
 
MI:14: 2676
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in methanol, dioxane or pyridine; insoluble in water, benzene or hexane.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-305
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380-305

Product Literature References

Inhibitors of inducible NO synthase expression: total synthesis of (S)-curvularin and its ring homologues: S. Elzner, et al.; ChemMedChem 3, 924 (2008), Abstract;
Birch reduction and its application in the total synthesis of natural products: G.S.R. Subba Rao; Pure Appl. Chem. 75, 1443 (2003),
Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi: Y. Yao, et al.; Mol. Pharmacol. 63, 383 (2003), Abstract; Full Text
Cytotoxic activity of macrocyclic metabolites from fungi: K. Horakova & V. Betina; Neoplasma 24, 21 (1977), Abstract;
Curvularin from penicillium baradicum Baghdadi NRRL 3754, and biological effects: R.F. Vesonder, et al.; J. Environ. Sci. Health B. 11, 289 (1976), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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