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Sparfloxacin

Fluoroquinolone antibacterial agent
 
ALX-380-302-G005 5 g 336.00 USD
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Fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. Shows photosensitizing effects.

Product Specification

Alternative Name:rel-5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, AT-4140
 
Formula:C19H22F2N4O3
 
MW:392.4
 
CAS:110871-86-8
 
MI:14: 8735
 
RTECS:VB1986500
 
Purity:≥98% (Assay)
 
Identity:Determined by IR.
 
Appearance:White to yellow crystalline solid.
 
Solubility:Soluble in 100% ethanol or water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-302
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380-302

Product Literature References

Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007), Abstract; Full Text
Sparfloxacin: a review: J.J. Schentag; Clin. Ther. 22, 372 (2000), (Review), Abstract;
The link between sunshine and phototoxicity of sparfloxacin: C. Pierfitte, et al.; Br. J. Clin. Pharmacol. 49, 609 (2000), Abstract; Full Text
Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria: L.J. Piddock & M. Zhu; Antimicrob. Agents Chemother. 35, 2423 (1991), Abstract; Full Text
Pharmacokinetics of a novel quinolone, AT-4140, in animals: S. Nakamura, et al.; Antimicrob. Agents Chemother. 34, 89 (1990), Abstract; Full Text
Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency: T. Miyamoto, et al.; J. Med. Chem. 33, 1645 (1990), Abstract;
In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone: S. Nakamura, et al.; Antimicrob. Agents Chemother. 33, 1167 (1989), Abstract; Full Text

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DNA gyrase
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