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Sarafloxacin . hydrochloride

Fluoroquinolone antibacterial agent
 
ALX-380-301-G005 5 g 56.00 USD
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Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis.

Product Specification

Alternative Name:6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid . hydrochloride, A-56620
 
Formula:C20H17F2N3O3 . HCl
 
MW:385.4 . 36.5
 
CAS:91296-87-6
 
MI:14: 8370
 
Purity:≥98% (Assay)
 
Identity:Identity determined by IR.
 
Appearance:White to yellow crystalline solid.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-301
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380-301

Product Literature References

Determination of temafloxacin, sarafloxacin, and difloxacin in bulk drug and dosage forms by high-performance liquid chromatography: J.F. Bauer, et al.; Pharm. Res. 7, 1177 (1990), Abstract;
In vitro activities of A-56619 (difloxacin) and A-56620, two aryl fluoroquinolones: A. Digranes & W.L. Dibb; Chemotherapy 34, 298 (1988), Abstract;
In-vitro activity of six fluorinated quinolones against Mycobacterium tuberculosis: O.G. Berlin, et al.; J. Antimicrob. Chemother. 19, 611 (1987), Abstract;
In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones: P.B. Fernandes, et al.; Antimicrob. Agents Chemother. 29, 201 (1986), Abstract; Full Text
Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents: D.T. Chu, et al.; J. Med. Chem. 28, 1558 (1985), Abstract;

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DNA gyrase
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