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Pefloxacin . mesylate . dihydrate

Fluoroquinolone antibacterial agent
 
ALX-380-298-G005 5 g 30.00 USD
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Fluoroquinolone antibacterial agent. Analog of norfloxacin. Prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerase). Highly effective against Staphylococcus aureus, E. coli, other enterobacteria and Pseudomonas aeruginosa. Excellent effcectivity against Gram-negative bacteria, also effective against Gram-positive bacteria.

Product Specification

Alternative Name:1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid . monomethanesulfonate . dihydrate
 
Formula:C17H20FN3O3 . CH4O3S . 2H2O
 
MW:333.4 . 96.1 . 36.0
 
CAS:149676-40-4
 
MI:14: 7066
 
RTECS:VB2002200
 
Purity:≥98% (Assay)
 
Appearance:White to yellow crystalline solid.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-298
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380-298

Product Literature References

Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals: K. Basavaiah, et al.; Acta Pharm. 57, 221 (2007), Abstract;
Binding interactions of pefloxacin mesylate with bovine lactoferrin and human serum albumin: J.C. Fan, et al.; J. Zhejiang Univ. Sci. B. 7, 452 (2006), Abstract; Full Text
In vitro effects of ciprofloxacin and pefloxacin on growth of normal human hematopoietic progenitor cells and on leukemic cell lines: E. Somekh, et al.; J. Pharmacol. Exp. Ther. 248, 415 (1989), Abstract;
Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives: H. Kondo, et al.; J. Med. Chem. 31, 221 (1988), Abstract;
In vitro activity of pefloxacin against gram-negative and gram-positive bacteria in comparison with other antibiotics: E. Debbia, et al.; Chemioterapia 6, 319 (1987), Abstract;
Activity of pefloxacin and thirteen other antimicrobial agents in vitro against isolates from hospital and genitourinary infections: B.M. Jones, et al.; J. Antimicrob. Chemother. 17, 739 (1986), Abstract;
Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys, and humans: G. Montay, et al.; Antimicrob. Agents Chemother. 25, 463 (1984), Abstract; Full Text

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DNA gyrase
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