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Fluoroquinolone antibacterial agent
ALX-380-297-G005 5 g 59.00 USD
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Fluoroquinolone with broad-spectrum antibacterial activity against most Gram-negative and Gram-positive bacteria. Effective against Mycobacterium tuberculosis.

Product Specification

Alternative Name:9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazin-6-carboxylic acid, DL 8280
MI:14: 6771
Purity:≥98% (UHPLC)
Appearance:White to yellow crystalline solid.
Solubility:Slightly soluble in water.
Long Term Storage:-20°C
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Product Literature References

Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007), Abstract; Full Text
Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing: R. Shi, et al.; J. Clin. Microbiol. 44, 4566 (2006), Abstract; Full Text
Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors: C. Fernandez-Tornero, et al.; J. Biol. Chem. 280, 19948 (2005), Abstract; Full Text
Mechanism of fluoroquinolone action: K. Drlica; Curr. Opin. Microbiol. 2, 504 (1999), Abstract;
Mechanism of differential activities of ofloxacin enantiomers: I. Morrissey, et al.; Antimicrob. Agents Chemother. 40, 1775 (1996), Abstract; Full Text
Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use: J.P. Monk & D.M. Campoli-Richards; Drugs 33, 346 (1987), Abstract;
Synthesis and antibacterial activities of optically active ofloxacin and its fluoromethyl derivative: S. Atarashi, et al.; Chem. Pharm. Bull. 35, 1896 (1987), Abstract;
A new synthesis of 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives including an antibacterial agent, ofloxacin: H. Egawa, et al.; Chem. Pharm. Bull. 34, 4098 (1986), Abstract;
Comparison of the antibacterial in vitro and in vivo activity of ofloxacin (HOE 280 DL 8280) and nalidixic acid analogues: G. Seibert, et al.; Eur. J. Clin. Microbiol. 2, 548 (1983), Abstract;
In vitro and in vivo activity of DL-8280, a new oxazine derivative: K. Sato, et al.; Antimicrob. Agents Chemother. 22, 548 (1982), Abstract; Full Text

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