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Norfloxacin nicotinate

Fluoroquinolone antibacterial agent
 
ALX-380-296-G001 1 g 30.00 USD
 
ALX-380-296-G005 5 g 55.00 USD
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Fluoroquinolone antibacterial agent. Derivative of norfloxacin with dramatically improved water solubility. Instantly dissociates into norfloxacin and nicotinic acid in the body therefore acting as norfloxacin. Inhibits bacterial DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase). Effective against Gram-negative bacteria; less effective against Gram-positive bacteria.

Product Specification

Alternative Name:1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid nicotinate
 
Formula:C16H18FN3O3 . C6H5NO2
 
MW:319.3 . 123.1
 
CAS:118803-81-9
 
Purity:≥98% (Assay)
 
Appearance:White to yellow crystalline solid.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-296
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380-296

Product Literature References

Norfloxacin nicotinate pharmacokinetics in unweaned and weaned calves: M. Gips & S. Soback; J. Vet. Pharmacol. Ther. 19, 130 (1996), Abstract;
Intravenous disposition kinetics, oral and intramuscular bioavailability and urinary excretion of norfloxacin nicotinate in donkeys: E. Lavy, et al.; J. Vet. Pharmacol. Ther. 18, 101 (1995), Abstract;
Clinical pharmacokinetic characterization of norfloxacin nicotinate in swine following systemic administration: M. Shem-Tov & G. Ziv; Zentralbl. Veterinarmed. B. 41, 60 (1994), Abstract;
Effect of lactation on single-dose pharmacokinetics of norfloxacin nicotinate in ewes: S. Soback, et al.; Antimicrob. Agents Chemother. 38, 2336 (1994), Abstract; Full Text
Norfloxacin nicotinate in the treatment of Pseudomonas aeruginosa infection in the genital tract of a bull: S. Marcus, et al.; Vet. Res. Commun. 18, 331 (1994), Abstract;
Tissue distribution and binding to plasma proteins of norfloxacin nicotinate after intramuscular administration in pigs: M. Shem-Tov, et al.; Zentralbl. Veterinarmed. B. 41, 257 (1994), Abstract;
Efficacy of norfloxacin nicotinate treatment of broiler breeders against Haemophilus paragallinarum: A. Lublin, et al.; Avian Dis. 37, 673 (1993), Abstract;

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