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Gatifloxacin

Fluoroquinolone antibacterial agent
 
ALX-380-291-G001 1 g 66.00 USD
 
ALX-380-291-G005 5 g 260.00 USD
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Fluoroquinolone with broad spectrum activity against Gram-negative and Gram-positive bacteria. Inhibits bacterial DNA-gyrase and topoisomerase IV. May cause dysglycemia. Stimulates short-term self-renewal in both human and mouse embryonic stem cells.

Product Specification

Alternative Name:AM-1155, 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
 
Formula:C19H22FN3O4
 
MW:375.4
 
CAS:112811-59-3
 
MI:14: 4376
 
Purity:≥98% (Assay)
 
Appearance:White to yellow crystalline powder.
 
Solubility:Soluble in water at pH 2-5 (40-60mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-291
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Product Literature References

Gatifloxacin produces both hypoglycemia and hyperglycemia: a retrospective study: H. Haerian, et al.; Am. J. Med. Sci. 335, 95 (2008), Abstract;
Gatifloxacin affects GLUT1 gene expression and disturbs glucose homeostasis in vitro: T.F. Ge, et al.; Eur. J. Pharmacol. 573, 70 (2007), Abstract;
Gatifloxacin-associated hypoglycemia: T. Ali, et al.; J. Okla. State Med. Assoc. 100, 425 (2007), Abstract;
Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniae: H. Fukuda, et al.; Antimicrob. Agents Chemother. 45, 1649 (2001), Abstract; Full Text
Gatifloxacin: C.M. Perry, et al.; Drugs 58, 683 (1999), (Review), Abstract;
Primary targets of fluoroquinolones in Streptococcus pneumoniae: H. Fukuda & K. Hiramatsu; Antimicrob. Agents Chemother. 43, 410 (1999), Abstract; Full Text
Activities of gatifloxacin compared to those of seven other agents against anaerobic organisms: L.M. Ednie, et al.; Antimicrob. Agents Chemother. 42, 2459 (1998), Abstract; Full Text
Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases: M. Takei, et al.; Antimicrob. Agents Chemother. 42, 2678 (1998), Abstract; Full Text
Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin: A. Bauernfeind; J. Antimicrob. Chemother. 40, 639 (1997), Abstract; Full Text

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