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Cyclosporin H

TPA/PMA inhibitor
 
ALX-380-286-M001 1 mg 98.00 USD
 
ALX-380-286-M005 5 mg 385.00 USD
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Immunologically inactive. Does not bind to immunophilin. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. BML-PE160) in mouse skin in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Potent and selective antagonist of formyl peptide receptor. Inhibits formyl peptide-induced superoxide formation.

Product Specification

Alternative Name:Csh-cyclosporin, 5-(N-Methyl-D-valine)-cyclosporin A
 
Formula:C62H111N11O12
 
MW:1202.6
 
Source:Isolated from Tolypocladium inflatum.
 
CAS:83602-39-5
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
380-286
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380-286

Product Literature References

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis: I. Snapkov, et al.; BMC Cancer 16, 490 (2016), Application(s): Inhibition of FPR1 signaling and Ca2+ mobilization, Abstract; Full Text
Antimicrobial peptide scolopendrasin VII, derived from the centipede Scolopendra subspinipes mutilans, stimulates macrophage chemotaxis via formyl peptide receptor 1: Y. J. Park, et al.; BMB Rep. 48, 479 (2015), Application(s): Cell Culture, Abstract; Full Text
Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S: G.Y. Cheung, et al. ; Sci. Rep. 5, 18023 (2015), Application(s): Cell culture, Abstract; Full Text
Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor: A.L. Stenfeldt, et al.; Inflammation 30, 224 (2007), Abstract;
Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine: A. de Paulis, et al.; J. Allergy Clin. Immunol. 98, 152 (1996), Abstract;
Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E: K. Wenzel-Seifert & R. Seifert; J. Immunol. 150, 4591 (1993), Abstract;
Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wenzel-Seifert, et al.; J. Immunol. 147, 1940 (1991), Abstract;
The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988), Abstract;

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