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Cyclosporin D

TPA/PMA inhibitor
 
ALX-380-284-M001 1 mg 98.00 USD
 
ALX-380-284-M005 5 mg 385.00 USD
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Weak immunosuppressor. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. BML-PE160) in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.

Product Specification

Alternative Name:Val2-cyclosporin, 7-L-Valine-cyclosporin A
 
Formula:C63H113N11O12
 
MW:1216.6
 
Source:Isolated from Fusarium solani.
 
CAS:63775-96-2
 
MI:14: 2752
 
Purity:≥95% (HPLC)
 
Appearance:Colorless to off-white crystalline solid.
 
Solubility:Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-284
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380-284

Product Literature References

The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988), Abstract;

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