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Amphotericin B (solubilized)

Antifungal agent
 
ALX-380-280-M250 250 mg 78.00 USD
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Antibiotic. Interferes with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out. Effective against yeasts and molds.

Product Specification

Alternative Name:Fungizone
 
Formula:C47H73NO17
 
MW:924.1
 
Source:Isolated from Streptomyces sp.
 
CAS:1397-89-3
 
MI:14: 585
 
RTECS:BU2625000
 
Formulation:Contains 45% Amphotericin B and 35% sodium deoxycholate for solubilization.
 
Appearance:Yellow to orange powder.
 
Activity:≥240 µg/mg
 
Solubility:Soluble in water (250µg/ml), DMSO or dimethyl formamide (30mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
380-280
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380-280

Product Literature References

Triggering of suicidal erythrocyte death by amphotericin B: H. Mahmud, et al.; Cell Physiol. Biochem. 24, 263 (2009), Abstract; Full Text
Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients. A randomized, placebo-controlled study: J. Tollemar, et al.; Transplantation 59, 45 (1995), Abstract;
Protective effect of granulocyte-colony stimulating factor against amphotericin B-induced myelosuppression in vitro: B.S. Charak, et al.; Br. J. Haematol. 88, 693 (1994), Abstract;
Inactivation by ionizing radiation of ion channels formed by polyene antibiotics amphotericin B and nystatin in lipid membranes: an inverse dose-rate behavior: C. Barth, et al.; Biophys. J. 64, 92 (1993), Abstract;
Effects of amphotericin B with combination chemotherapy on response rates and on survival in non-small cell carcinoma of the lung: C.A. Presant, et al.; Cancer Treat. Rep. 68, 651 (1984), Abstract;
Amphotericin B-induced sensitivity to actinomycin D in drug-resistant Hela cells: J. Medoff, et al.; Cancer Res. 35, 2548 (1975), Abstract; Full Text

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