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Cycloheximide

Protein synthesis inhibitor
 
ALX-380-269-G001 1 g 56.00 USD
 
ALX-380-269-G005 5 g 151.00 USD
 
Replaces Prod. #: BML-GR310

Antibiotic. Inhibits protein synthesis in eukaryotes by interfering with the translocation step. Induces apoptosis in tumor cell lines but can also delay or inhibit apoptosis induced by other agents. Widely used for selection of resistant strains of yeast and fungy, controlled inhibiton of protein synthesis for detecton of short-lived proteins and super-induction of protein expression. At 10µg/ml cycloheximide totally inhibits protein synthesis in mouse thymocytes.

Product Specification

Alternative Name:Actidione, Naramycin A, 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide
 
Formula:C15H23NO4
 
MW:281.3
 
Source:Isolated from Streptomyces griseus.
 
CAS:66-81-9
 
MI:14: 2728
 
RTECS:MA4375000
 
Purity:≥95% (TLC)
 
Appearance:White to light yellow powder.
 
Activity:Potency is >900units/mg.
 
Solubility:Soluble in water (20mg/ml), 100% ethanol (25mg/ml), methanol , DMSO (25mg/ml) or acetone.
 
Long Term Storage:-20°C
 
380-269
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380-269

Product Literature References

Specific dual effect of cycloheximide on B lymphocyte apoptosis: involvement of CPP32/caspase-3: Cl Lemaire et al.; Biochem. Pharmacol. 58, 85 (1999), Abstract;
Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties: C. Christner, et al.; J. Med. Chem. 42, 3615 (1999), Abstract;
Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells: Q. Lu & R.L. Mellgren; Arch. Biochem. Biophys. 334, 175 (1996), Abstract;
J. Alten et al.; Cell. Immunol. 161, 98 (1995),
A novel protein expressed in mammalian cells undergoing apoptosis: R.J. Grand et al.; Exp. Cell. Res. 218, 439 (1995), Abstract;
Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis: S.C. Chow, et al.; Exp. Cell Res. 216, 149 (1995), Abstract;
Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone: J. Lotem & L. Sachs; Cell. Growth. Differ. 6, 647 (1995), Abstract;
DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels: P. Waring; J. Biol. Chem. 265, 14476 (1990), Abstract; Full Text
Early estrogen-induced metabolic changes and their inhibition by actinomycin D and cycloheximide in human breast cancer cells: 31P and 13C NMR studies: M. Neeman & H. Degani; PNAS 86, 5585 (1989), Abstract; Full Text
Effects of cycloheximide on thermotolerance expression, heat shock protein synthesis, and heat shock protein mRNA accumulation in rat fibroblasts: R.B. Widelitz, et al.; Mol. Cell. Biol. 6, 1088 (1986), Abstract; Full Text
The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes: T.G. Obrig, et al.; J. Biol. Chem. 246, 174 (1971), Abstract; Full Text

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