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Amidepsine D

DGAT inhibitor
 
ALX-380-263-M001 1 mg 276.00 USD
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Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=17.5µM) and Raji cells (IC50=2.8µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.

Product Specification

Formula:C26H24O10
 
MW:496.5
 
Source:Isolated from fungal strain FO-2943.
 
CAS:79786-34-8
 
Purity:≥95% (HPLC)
 
Appearance:White to light pink powder.
 
Solubility:Soluble in methanol (1mg/ml); insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Manufacturer:Fungal strain courtesy of the Kitasato Institute, Tokyo.
 
380-263
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380-263

Product Literature References

Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995), Abstract;
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995), Abstract;

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