Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=10.2µM) and Raji cells (IC50=15.5µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Details
| Formula: | C29H29NO11 |
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| MW: | 567.6 |
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| Source: | Isolated from fungal strain FO-2943. |
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| CAS: | 169181-28-6 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Pale white to pale yellow powder. |
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| Solubility: | Soluble in methanol, ethyl acetate or benzene; insoluble in water or hexane. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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| Manufacturer: | Fungal strain courtesy of the Kitasato Institute, Tokyo. |
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Product Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot.
48, 937 (1995),
Abstract;
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot.
48, 942 (1995),
Abstract;
