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Idarubicin . hydrochloride

Topoisomerase IIα inhibitor
 
ALX-380-260-M005 5 mg 132.00 USD
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More potent, lipophilic and antineoplastic analog of daunorubicin. DNA-damaging effect includes DNA oxidation and methylation, DNA intercalation, inhibition of DNA synthesis, induction of DNA strand breaks and delay of cell cycle progression. Inhibitor of topoisomerase IIα. Produces endonucleolytic cleavage and is a marker of apoptosis.

Product Specification

Alternative Name:Idamycin, DMDR, 4-Demethoxydaunorubicin
 
Formula:C26H27NO9 . HCl
 
MW:497.5 . 36.5
 
Source:Synthetic.
 
CAS:57852-57-0
 
MI:14: 4886
 
RTECS:HB7877000
 
Purity:≥98% (HPLC)
 
Identity:Determined by IR.
 
Appearance:Orange crystalline solid.
 
Solubility:Soluble in water or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-260
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380-260

Product Literature References

Repair of idarubicin-induced DNA damage: A cause of resistance?: D.C. Dartsch & F. Gieseler; DNA Repair (Amst) 6, 1618 (2007), Abstract;
A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002), Abstract; Full Text
Study of apoptosis-related responses of leukemic blast cells to in vitro anthracycline treatment: M.A. Belaud-Rotureau, et al.; Leukemia 14, 1266 (2000), Abstract;
Antitumor activity of idarubicin, a derivative of daunorubicin, against drug sensitive and resistant P388 leukemia: T. Tsuruo, et al.; Anticancer Res. 13, 357 (1993), Abstract;
Idarubicin (4-demethoxydaunorubicin). A preliminary overview of preclinical and clinical studies: F. Ganzina, et al.; Invest. New Drugs 4, 85 (1986), Review, Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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