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Siomycin A

FOXM1 inhibitor
 
ALX-380-243-MC05 0.5 mg 526.00 USD
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Macrocyclic thiazole antibiotic with potent and selective antibacterial activity. Potent inhibitor of the oncogenic transcription factor forkhead box M1 (FoxM1) that downregulates protein and mRNA levels of FoxM1. Inhibits FoxM1 induced cell growth.

Product Specification

Alternative Name:Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin
 
Formula:C71H81N19O18S5
 
MW:1648.9
 
Source:Isolated from Streptomyces sp. MST-AS4617.
 
CAS:12656-09-6
 
RTECS:VX0600000
 
Purity:≥95% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-243
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380-243

Product Literature References

Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells: U.G. Bhat, et al.; PLoS One 4, e5592 (2009), Abstract;
Future roles for FoxM1 inhibitors in cancer treatments: G.R. Adami & H. Ye; Future Oncol. 3, 1 (2007), Abstract; Full Text
Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1: S.K. Radhakrishnan, et al.; Cancer Res. 22, 364 (2006), Abstract; Full Text
Studies on siomycin. I. Physicochemical properties of siomycins A, B and C: M. Ebata, et al.; J. Antibiot. (Tokyo) 22, 364 (1969), Abstract;

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