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RNA polymerase inhibitor
ALX-380-240-MC05 0.5 mg 315.00 USD
ALX-380-240-M001 1 mg 538.00 USD
ALX-380-240-M005 5 mg 1,499.00 USD
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Antibiotic. More hydrophobic analog of the antibiotic thiolutin (Prod. No. BML-CT107) with selective antitumor activity. Potent inhibitor of bacterial and yeast RNA polymerases and of fungal mannan and glucan formation.

Product Specification

Alternative Name:Propionylpyrrothione, Farcinicin
Source:Isolated from Streptomyces thioluteus.
Purity:≥98% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:Yellow to orange solid.
Solubility:Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
Short Term Storage:+4°C
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
Handling:After reconstitution protect from light at -20°C.
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Product Literature References

Anticancer properties of dithiolopyrrolones: J.M. Webster, et al.; US Patent 6,020,360, (2000),
Studies on a common hydrolysis product of thiolutin and aureothricin: W.D. Celmer & I.A. Solomons; Antibiot. Annu. 622, (1953),

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