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Ristocetin A . sulfate

Antibiotic. Inducer of platelet aggregation
 
ALX-380-237-M010 10 mg 247.00 USD
 
Potent antibacterial antibiotic. Induces platelet aggregation by binding to a factor absent in people suffering from von Willebrand’s disease and is therefore an important diagnostic tool. Chiral selector for the separation of enantiomers by HPLC, TLC and electrophoresis.

Product Specification

Alternative Name:Ristocetin . sulfate, Ristomycin III . sulfate, Spontin . sulfate, Riston . sulfate
 
Formula:C95H110N8O44 . H2SO4
 
MW:2067.9 . 98.0
 
Source:Isolated from Amycolatopsis sp. MST-AS5924.
 
CAS:11021-66-2
 
MI:14: 8234
 
RTECS:VJ8595000
 
Purity:≥95% (HPLC)
 
Appearance:Light tan solid.
 
Solubility:Soluble in water, methanol or DMSO.
 
Long Term Storage:-20°C
 
380-237
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380-237

Product Literature References

HPLC separation of amino acid enantiomers and small peptides on macrocyclic antibiotic-based chiral stationary phases: a review: I. Ilisz, et al.; J. Sep. Sci. 29, 1305 (2006), (Review), Abstract;
A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX: H. Matsuno, et al.; J. Thromb. Haemost. 1, 2636 (2003), Abstract;
Cooperativity and anti-cooperativity between ligand binding and the dimerization of ristocetin A: asymmetry of a homodimer complex and implications for signal transduction: Y.R. Cho, et al.; Chem. Biol. 3, 207 (1996), Abstract;
Ristocetin--a new tool in the investigation of platelet aggregation: M.A. Howard and B.G. Firkin; Thromb. Diath. Haemorrh. 26, 362 (1971), Abstract;
Ristocetin A and B, two new antibiotics. Isolation and properties: J.E. Philip, et al.; Antibiot. Annu. 1956-1957, 699 (1957),

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