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Piericidin A

NADH-ubiquinone oxidoreductase inhibitor
 
ALX-380-235-M002 2 mg 250.00 USD
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Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.

Product Specification

Alternative Name:Piericidin A1, Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D
 
Formula:C25H37NO4
 
MW:415.6
 
Source:Isolated from Streptomyces sp. MST-AS5364.
 
CAS:2738-64-9
 
RTECS:YD4588000
 
Purity:≥95% (HPLC)
 
Appearance:Pale yellow oil.
 
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. Poorly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-235
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380-235

Product Literature References

Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2: S. Grefte, et al.; Biochim. Biophys. Acta. 1853, 1606 (2015), Application(s): Cell Culture, Abstract;
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator: J.H. Hwang, et al.; J. Cell. Physiol. 215, 243 (2008), Abstract;
Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I: I. Prieur, et al.; Biochim. Biophys. Acta 1504, 173 (2001), Abstract;
The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors: E. Darrouzet, et al.; FEBS Lett. 431, 34 (1998), Abstract;
Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase: T. Friedrich, et al.; Eur. J. Biochem. 219, 691 (1994), Abstract;
Piericidin A: a new inhibitor of mitochondrial electron transport: C. Hall, et al.; BBRC 25, 373 (1966), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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